Sharpstown High School is a secondary school at 7504 Bissonnet Street in Greater Sharpstown, Houston, Texas, United States with a zip code of 77074. It serves grades 9 through 12 and is a part of the Houston Independent School District.

The school serves part of Sharpstown, which was Houston's first master-planned community. It also serves the neighborhoods of Robindell, Braeburn Glen, Braeburn Terrace, Braeburn Valley, Braeburn Valley West, and parts of Fondren Southwest.