Sharpstown High School originally opened in 1968 as Sharpstown Junior-Senior High School, but separated from the middle school and moved to its current location the following year. 

A new Sharpstown High School facility opened in 2018.

In 2023, Principal TJ Cotter oversaw a series of transformations at Sharpstown High School, which included enhancing the campus with murals that vividly capture the rich history and vibrant school spirit of Sharpstown.