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Below is a partial list of notable people who attended or graduated from HISD schools. To nominate someone for inclusion on the list, please send an email that contains the person’s full given name (maiden name, if changed by marriage), date of graduation, high school attended, and significant accomplishments to info@houstonisd.org for consideration.
- Gregory Anderson (1983) — professional basketball player (forward) sometimes known as "Cadillac"; has played for San Antonio Spurs, Milwaukee Bucks, Denver Nuggets, Detroit Pistons, and Atlanta Hawks
- Clifford Branch (1967) — former professional football player; played wide receiver for Oakland (and later, the Los Angeles) Raiders for more than a decade; three-time Super Bowl winner; also attended Fairchild Elementary and Attucks Middle Schools
- Milton Carroll (1968) — founder of oil equipment manufacturing company Instrument Products, Inc.; chairman of CenterPoint Energy´s Board of Directors
- Ralph Cooper (1966) — KCOH Radio (1430 AM) Sports Rap host, veteran sports broadcaster and sports writer; also attended Grimes ES and Attucks MS
- Terri Ellis (1982) — founding member of the girl group EnVogue; recorded a string of hits in the early 1990s, including My Lovin' (Never Gonna Get It), Free Your Mind, and the theme song on the movie soundtrack to Set It Offstarring Queen Latifah
- Christopher Hudson (1990) — former professional football player who played for the Atlanta Falcons; drafted 1995; spent seven years in the NFL
- Brian Iwuh (2002) — retired professional linebacker who played for the Jacksonville Jaguars, Chicago Bears, and Denver Broncos
- Michael "Mike" Singletary (1977) — Hall-of-Fame professional football player (linebacker) for the Chicago Bears
- Lemuel Stinson (1984) — professional football player (defensive back) in the late 1980s and early 1990s; played for the Chicago Bears
- Wesley Weston (1999) — rap singer known as L´il Flip; has tracks featured on the Sony PlayStation 2 game NBA Live 2004, and the Electronic Arts-Sports game "NFL Street"